Leber's Hereditary Optic Neuropathy (LHON) primarily affects which group?

Leber's Hereditary Optic Neuropathy (LHON) primarily affects young males. This condition is a genetic disorder that leads to the loss of vision due to cell death in the optic nerve, and its onset typically occurs in males in their late teens to early thirties. The genetic mutation involved in LHON is related to the mitochondria, and it is observed that males are more susceptible to the condition, which contributes to the higher prevalence in this demographic compared to females and other age groups.

The disease's manifestation at a younger age in males, rather than older adults or children, is a crucial aspect that aids in identifying and understanding the epidemiology of LHON. This risk distribution pattern emphasizes the importance of screening and genetic counseling for young males who may have a family history of the condition.